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DUSP1 Polyclonal Antibody
HVH1, MKP1, CL100, MKP-1, PTPN10
货号:YBAP12586
价格: 980/1280/1890
Immunogen: Synthetic peptide of human DUSP1
Synonym:
HVH1, MKP1, CL100, MKP-1, PTPN10
Calculated MW: 39kDa
Observed MW: Refer to figures
Source:
Rabbit
Isotype:
IgG
Reactivity: H,M,R;

Clonality: Polyclonal


Application:
ELISA WB IHC
Purify:
Affinity purification
Concentration:
2.2mg/ml
Storage Buffer:
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
DUSP1 Polyclonal Antibody


Western blot analysis of Mouse brain tissue, using DUSP1 Polyclonal Antibody at dilution of 1:363

Protocols:
Buffer-Formulation WB-Guide IHC-Guide IP-Guide IF-Guide
Background:
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

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