工作时间 :
周一~~周五
9:00 -18:00
在非工作时间,您可以通过邮件订购产品,订购时请写明详细联系方式,谢谢支持!
销售:18321282235
技术:021-60514606
传真:021-37680378
顾经理微信 扫一扫,关注我们
FAS Polyclonal Antibody
APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
货号:YBAP14081 |
|
规格: 50ul/100ul/200ul |
|
价格: 980/1280/1890 |
Immunogen: | Recombinant protein of human FAS | ||
Synonym: |
APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6 | ||
Calculated MW: | 38kDa | ||
Observed MW: | Refer to figures | ||
Source: |
Rabbit |
Isotype: |
IgG | ||
Application: |
ELISA WB IHC | ||
Purify: |
Affinity purification | ||
Concentration: |
1.4mg/ml | ||
Storage Buffer: |
PBS with 0.05% sodium azide, 50% glycerol, pH7.3 | ||
Storage: |
Store at -20℃. Avoid freeze / thaw cycles. |
Western blot analysis of Human fetal brain tissue, using FAS Polyclonal Antibody at dilution of 1:550 |
Protocols: |
Buffer-Formulation WB-Guide IHC-Guide IP-Guide IF-Guide |
||
Background: |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
|
部门 |
姓名 | 手机 | |||
销售部 | 顾先生 | 1916510334@qq.com | 18321282235 | 1916510334 | |
技术部 | 技术支持 | 1781364813@qq.com | 13816899465 | 1781364813 |
全国免费电话:18321282235
销售: 18321282235
86-21-60514606
技术: 13816899465
传真: 021-37680378
The latest products