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ERBB3 Polyclonal Antibody
HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3
货号:YBAP14260
价格: 980/1280/1890
Immunogen: Recombinant protein of human ERBB3
Synonym:
HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3
Calculated MW:
Observed MW:
Source:
Rabbit
Isotype:
IgG
Reactivity: H,M,R;

Clonality: Polyclonal


Application:
ELISA IHC
Purify:
Affinity purification
Concentration:
0.6mg/ml
Storage Buffer:
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
ERBB3 Polyclonal Antibody


Immunohistochemistry of Human breast cancer using ERBB3 Polyclonal Antibody at dilution of 1:20

Protocols:
Buffer-Formulation WB-Guide IHC-Guide IP-Guide IF-Guide
Background:
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

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