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RAF1 Polyclonal Antibody
NS5; CRAF; Raf-1; c-Raf
货号:YBAP14280
价格: 980/1280/1890
Immunogen: Recombinant protein of human RAF1
Synonym:
NS5; CRAF; Raf-1; c-Raf
Calculated MW:
Observed MW:
Source:
Rabbit
Isotype:
IgG
Reactivity: H,M,R;

Clonality: Polyclonal


Application:
ELISA IHC
Purify:
Affinity purification
Concentration:
1.6mg/ml
Storage Buffer:
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
RAF1 Polyclonal Antibody


Immunohistochemistry of Human colon cancer using RAF1 Polyclonal Antibody at dilution of 1:40

Protocols:
Buffer-Formulation WB-Guide IHC-Guide IP-Guide IF-Guide
Background:
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

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