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RFFL Polyclonal Antibody
CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN
货号：YBAP15642 |
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规格： 50ul/100ul/200ul |
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价格： 980/1280/1890 |
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| Immunogen： | Recombinant protein of human RFFL | ||
Synonym: |
CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN | ||
| Calculated MW: | |||
| Observed MW: | |||
Source: |
Rabbit | ||
Isotype: |
IgG | Reactivity: H,M,R; Clonality: Polyclonal  |
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Application: |
ELISA IHC | ||
Purify: |
Affinity purification | ||
Concentration: |
1.4mg/ml | ||
Storage Buffer: |
PBS with 0.05% sodium azide, 50% glycerol, pH7.3 | ||
Storage: |
Store at -20℃. Avoid freeze / thaw cycles. |
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| Immunohistochemistry of Human liver cancer using RFFL Polyclonal Antibody at dilution of 1:25 |
Protocols： |
Buffer-Formulation WB-Guide IHC-Guide IP-Guide IF-Guide |
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Background: |
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.
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