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CXCR2 Polyclonal Antibody
CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b
货号:YBAP15892
价格: 980/1280/1890
Immunogen: Synthetic peptide of human CXCR2
Synonym:
CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b
Calculated MW: 41kDa
Observed MW: Refer to figures
Source:
Rabbit
Isotype:
IgG
Reactivity: H;

Clonality: Polyclonal


Application:
ELISA WB
Purify:
Affinity purification
Concentration:
0.5mg/ml
Storage Buffer:
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
CXCR2 Polyclonal Antibody


Western blot analysis of Human serum solution, using CXCR2 Polyclonal Antibody at dilution of 1:125

Protocols:
Buffer-Formulation WB-Guide IHC-Guide IP-Guide IF-Guide
Background:
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

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