Alternative Names:

cyclin D2; G1/S-specific cyclin D2

Application:

WB

Reactivity:

Human,Mouse,Rat

Dilution:

WB 1:500-1:2000

	Western blot analysis of Cyclin D2 expression in 293 cells

Purification:

Affinity-chromatography

Specificity:

Cyclin D2 Antibody detects endogenous levels of total Cyclin D2

Immunogen:

A synthesized peptide derived from human Cyclin D2

Description:

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.