Alternative Names:

FIP-3, FIP3, I-kappa-B kinase gamma, IKBKG, IKK-gamma, IKKAP1, IKKG, IkB kinase gamma subunit, IkB kinase-associated protein 1, Inhibitor of nuclear factor kappa-B kinase gamma subunit, NEMO, NF-kappaB essential modifier, NF-kappaB essential modulator, mF

Application:

WB,IF

Reactivity:

Human,Mouse

Dilution:

WB 1:500-1:2000 IF 1:100-1:500

	Western blot analysis of IKK-γ expression in 293 cells

Purification:

Affinity-chromatography

Specificity:

IKK-γ Antibody detects endogenous levels of total IKK-γ

Immunogen:

A synthesized peptide derived from human IKK-γ

Description:

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity (By similarity). Essential for viral activation of IRF3.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.