Alternative Names:

EC 2.7.7.49, EST2, HEST2, TCS1, TERT, TRT, Telomerase catalytic subunit, Telomerase reverse transcriptase

Application:

WB

Reactivity:

Human

Dilution:

WB 1:500-1:2000

	Western blot analysis of TERT expression in Jurkat cell extracts

Purification:

Affinity-chromatography

Specificity:

TERT Antibody detects endogenous levels of total TERT

Immunogen:

A synthesized peptide derived from human TERT

Description:

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.