Alternative Names:

EC 2.7.11.11, KAPCA, PKA C-alpha, PKA-alpha, PKACA, PRKACA, alpha-catalytic subunit, cAMP-dependent protein kinase, cAMP-dependent protein kinase, alpha-catalytic subunit, kinase PKA C-alpha

Application:

WB,IHC,IF

Reactivity:

Human,Mouse,Rat

Dilution:

WB 1:500-1:2000 IHC 1:50-1:200 IF 1:100-1:500

	Western blot analysis of PKA CAT expression in mouse brain cells

Purification:

Affinity-chromatography

Specificity:

PKA CAT Antibody detects endogenous levels of total PKA CAT

Immunogen:

A synthesized peptide derived from human PKA CAT

Description:

Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.