Alternative Names:

CDKN2A; CDKN2; MTS1; isoforms 1/2/3; Cyclin-dependent kinase 4 inhibitor A; CDK4I; P16INK4; p16INK4a; Multiple tumor suppressor 1;

Application:

WB IHC ICC/IF IP FC

Reactivity:

Human

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:30 FC 1:100

	Western blot analysis of p16 INK expression in 293T cell lysate.
	Immunohistochemical analysis of paraffin-embedded human gastric, using p16 INK Antibody.

Purification:

Affinity-chromatography

Specificity:

p16 INK Antibody detects endogenous levels of total p16 INK

Immunogen:

A synthesized peptide derived from human p16 INK

Description:

p16-INK4A a cell-cycle regulatory protein that Interacts with CDK4 and CDK6, inhibiting their ability to interact with cyclins D. Inhibits the phosphorylation of the retinoblastoma protein by CDK4 or CDK6. Four alternatively spliced isoforms have been reported.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.