Alternative Names:

FLJ21925; ICBP90; MGC138707; Np95; RNF106; hNP95;

Application:

WB IHC IF IP CHIP

Reactivity:

Human

Dilution:

WB 1:500-1:2000 IHC 1:50-1:200 IF 1:20-1:50 IP 1:20-1:50 CHIP 1:20-1:50

	Western blot analysis of extracts of variouscell lines, using UHRF1 antibody.

Purification:

Affinity-chromatography

Specificity:

UHRF1 Antibody detects endogenous levels of total UHRF1

Immunogen:

A synthesized peptide derived from human UHRF1

Description:

UHRF1 binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. It is important for G1/S transition and may be involved in DNA repair and chromosomal stability. UHRF1's ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.