Alternative Names:

CBP; CREB binding protein; CREB-binding protein; CREBBP; KAT3A; RSTS

Application:

WB IHC IF/ICC

Reactivity:

Human, Mouse

Dilution:

WB 1:500~1:3000 IHC 1:50~1:200 IF/ICC 1:100~1:500

	Western blot analysis on HeLa cell lysate using CREB-BP Antibody

Purification:

Affinity-chromatography

Specificity:

CREB-BP antibody detects endogenous levels of total CREB-BP

Immunogen:

A synthesized peptide derived from human CREB-BP

Description:

CBP a protein acetyltransferase that can transcriptionally activate histones. Acetylates the NCOA3 coactivator. Binds specifically to phosphorylated CREB1 and enhances its transcriptional activity toward cAMP-responsive genes. Methylation of the KIX domain by CARM1 blocks association with CREB, blocking CREB signaling, and activating the apoptotic response. Found in a complex containing NCOA2, NCOA3, IKKA, IKKB, and IKBKG. Probably part of a complex with HIF1A and EP300.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.