Alternative Names:

Collagen alpha-1(XVIII) chain [Precursor], Endostatin, COIA1

Application:

IHC

Reactivity:

Human, Mouse,

Dilution:

IHC 1:50-1:200

Purification:

Affinity-chromatography

Specificity:

Collagen alpha 1 XVIII Antibody detects endogenous levels of Collagen alpha 1 XVIII

Immunogen:

A synthesized peptide derived from human Collagen alpha 1 XVIII

Description:

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Three transcripts have been identified for this gene.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.