Alternative Names:

COP9 complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis); COP9 signalosome complex subunit 3; COPS3; CSN3; JAB1-containing signalosome subunit 3; SGN3; Signalosome subunit 3

Application:

WB IF/ICC

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500~1:3000 IF/ICC 1:100~1:500

	Western blot analysis on LOVO cell lysate using COPS3 Antibody

Purification:

Affinity-chromatography

Specificity:

COPS3 antibody detects endogenous levels of total COPS3

Immunogen:

A synthesized peptide derived from human COPS3

Description:

COPS3 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.