Alternative Names:

CD45; B220; GP180; LCA; PTPRC; T200 leukocyte common antigen;

Application:

IHC IF

Reactivity:

Human, Mouse, Rat

Dilution:

IHC: 1:50~1:200 FC: 1:100~1:500

	Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using CD45 antibody.

Purification:

Affinity-chromatography

Specificity:

CD45 Antibody detects endogenous levels of total CD45

Immunogen:

A synthesized peptide derived from human CD45

Description:

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.