Alternative Names:

BNMD17; G protein coupled receptor 48; G-protein coupled receptor 48; GPR48; Leucine-rich repeat-containing G protein-coupled receptor 4; Leucine-rich repeat-containing G-protein coupled receptor 4; LGR4; LGR4_HUMAN;

Application:

WB

Reactivity:

Human, Mouse, Rat

Dilution:

WB: 1:500~1:2000

	Western blot analysis of GPR48 expression in Jurkat cell lysate,The lane on the left is treated with the antigen-specific peptide.

Purification:

Affinity-chromatography

Specificity:

GPR48 Antibody detects endogenous levels of total GPR48

Immunogen:

A synthesized peptide derived from human GPR48

Description:

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.