Alternative Names:

AD3; FAD; presenilin 1; Presenilin-1; Presenilin-1 CTF subunit; Presenilin-1 CTF12; Presenilin-1 NTF subunit; Protein S182; PS-1; PS1; PS1-CTF12; PSEN1; PSN1; PSNL1; S182

Application:

WB IHC

Reactivity:

Human

Dilution:

WB 1:500~1:3000 IHC 1:50~1:200

	Western blot analysis on RAW264.7 cell lysate using Presenilin 1 Antibody

Purification:

Affinity-chromatography

Specificity:

Presenilin 1 antibody detects endogenous levels of total Presenilin 1

Immunogen:

A synthesized peptide derived from human Presenilin 1

Description:

PSEN1 probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Regulates epithelial- cadherin function.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.