Alternative Names:

CD120a; FPF; MGC19588; p55; p55-R; p60; TBP1; TBPI; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-RI; TNFAR; TNFR-I; TNFR1; TNFR55; TNFR60; TNFRSF1A; TNR1A; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor 1; tumor necrosis factor receptor

Application:

IHC

Reactivity:

Human, Mouse, Rat

Dilution:

IHC 1:50-1:200

Purification:

Affinity-chromatography

Specificity:

TNFR1 Antibody detects endogenous levels of TNFR1

Immunogen:

A synthesized peptide derived from human TNFR1

Description:

TNF-R1 Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.