Alternative Names:

BS4; NEDD8 ultimate buster 1; NEDD8 ultimate buster-1; Negative regulator of ubiquitin-like proteins 1; NUB1; NUB1L; NY-REN-18 antigen; NYREN18; Renal carcinoma antigen NY-REN-18

Application:

WB IHC

Reactivity:

Human, Mouse

Dilution:

WB 1:500~1:3000 IHC 1:50~1:200

	Western blot analysis on COS7 cell lysate using NYREN18 Antibody

Purification:

Affinity-chromatography

Specificity:

NYREN18 antibody detects endogenous levels of total NYREN18

Immunogen:

A synthesized peptide derived from human NYREN18

Description:

NYREN18 Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8 and its conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. Induced by beta and gamma interferons. Directly interacts with NEDD8 and PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.