Alternative Names:

APO2; CD261; cytotoxic TRAIL receptor; Death receptor 4; DR4; MGC9365; TNF-related apoptosis inducing ligand receptor 1; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TR10A; TRAIL receptor 1; TRAIL-R1; TRAILR-1; TRAILR1; Tumor necrosis fact

Application:

WB

Reactivity:

Human

Dilution:

WB 1:500~1:3000

	Western blot analysis on K562 cell lysate using TR10A Antibody

Purification:

Affinity-chromatography

Specificity:

TR10A antibody detects endogenous levels of total TR10A

Immunogen:

A synthesized peptide derived from human TR10A

Description:

TRAIL-R1 Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.