Alternative Names:

PDZ domain-containing protein 2, PDZ domain-containing protein 3, Activated in prostate cancer protein, Processed PDZ domain-containing protein 2, PDZD2, AIPC, KIAA0300, PDZK3

Application:

IHC IF/ICC

Reactivity:

Human, Mouse, Rat

Dilution:

IHC 1:50-1:200 IF/ICC 1:100-1:500

Purification:

Affinity-chromatography

Specificity:

PDZD2 Antibody detects endogenous levels of PDZD2

Immunogen:

A synthesized peptide derived from human PDZD2

Description:

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. Two transcript variants encoding different isoforms have been found for this gene.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.