Alternative Names:

MBD3; methyl-CpG binding domain protein 3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3

Application:

WB

Reactivity:

Human, Mouse

Dilution:

WB 1:500~1:3000

	Western blot analysis on Jurkat cell lysate using MBD3 Antibody

Purification:

Affinity-chromatography

Specificity:

MBD3 antibody detects endogenous levels of total MBD3

Immunogen:

A synthesized peptide derived from human MBD3

Description:

MBD3 methyl-CpG binding (MBD) proteins appear to bind differentially methylated domains (DMDs) of DNA, to recruit repression complexes, and to silence the locus. The methyl CpG binding domain of human MBD3 may not directly bind mCpG but does interact with the NuRD/Mi2 components HDAC1 and MTA2. Plays a role in histone deacetylation and nucleosome remodeling. Increased levels have been reported in lung cancer and glioblastomas and may be a therapeutic target.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.