Alternative Names:

CD120b; p75; p75 TNF receptor; p75TNFR; p80 TNF-alpha receptor; soluble TNFR1B variant 1; TBP-2; TBPII; TNF-R-II; TNF-R2; TNF-R75; TNF-RII; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRSF1B; TNR1B; tumor necrosis factor beta receptor; tumor necrosis factor

Application:

WB IF/ICC

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500~1:3000 IF/ICC 1:100~1:500

	Western blot analysis on LOVO cell lysate using TNF-R2 Antibody

Purification:

Affinity-chromatography

Specificity:

TNF-R2 antibody detects endogenous levels of total TNF-R2

Immunogen:

A synthesized peptide derived from human TNF-R2

Description:

TNF-R2 Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.