Alternative Names:

Cardiac lineage protein 1; CLP1; EDG1; Estrogen down-regulated gene 1 protein; FLJ13562; hexamethylene bis-acetamide inducible 1; Hexamethylene bis-acetamide-inducible protein 1; hexamethylene bisacetamide-inducible protein; hexamethylene-bis-acetamide-in

Application:

WB IF/ICC

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500-1:2000 IF/ICC 1:100-1:500

	Western blot analysis on NIH-3T3 cell lysate using HEXIM1 Antibody

Purification:

Affinity-chromatography

Specificity:

HEXIM1 Antibody detects endogenous levels of HEXIM1

Immunogen:

A synthesized peptide derived from human HEXIM1

Description:

HEXIM1 Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.