Alternative Names:

BHLHA27; Class A basic helix-loop-helix protein 27; EHAND; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; HAND1; heart and neural crest derivatives expressed 1; Heart- and neural crest derivatives

Application:

IF/ICC

Reactivity:

Human, Mouse, Rat

Dilution:

IF/ICC 1:100-1:500

Purification:

Affinity-chromatography

Specificity:

HAND1 Antibody detects endogenous levels of HAND1

Immunogen:

A synthesized peptide derived from human HAND1

Description:

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.