Alternative Names:

Cytochrome P450 2C19, EC 1.14.13.80, (R)-limonene 6-monooxygenase, EC 1.14.13.48, (S)-limonene 6-monooxygenase, EC 1.14.13.49, (S)-limonene 7-monooxygenase, CYPIIC19, P450-11A, Mephenytoin 4-hydroxylase, CYPIIC17, P450-254C, CYP2C19, CP2CJ

Application:

WB

Reactivity:

Human,

Dilution:

WB 1:500-1:2000

	Western blot analysis on 293 cell lysate using Cytochrome P450 2C19 Antibody

Purification:

Affinity-chromatography

Specificity:

Cytochrome P450 2C19 Antibody detects endogenous levels of Cytochrome P450 2C19

Immunogen:

A synthesized peptide derived from human Cytochrome P450 2C19

Description:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.