Alternative Names:

EC 2.7.11.1; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPK5; MAPKAP kinase 5; p38-regulated/activated protein kinase; PRAK

Application:

WB

Reactivity:

Human, Mouse,

Dilution:

WB 1:500-1:2000

	Western blot analysis on K562 cell lysate using MAPKAPK5 Antibody

Purification:

Affinity-chromatography

Specificity:

MAPKAPK5 Antibody detects endogenous levels of MAPKAPK5

Immunogen:

A synthesized peptide derived from human MAPKAPK5

Description:

The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.