Alternative Names:

H2B histone family, member S; H2B/s; H2BFS; Histone H2B type F-S; Histone H2B.s

Application:

WB IHC IF/ICC

Reactivity:

Human, Mouse,

Dilution:

WB 1:500-1:2000 IHC 1:50-1:200 IF/ICC 1:100-1:500

	Western blot analysis on COS7 cell lysate using Histone H2B Antibody

Purification:

Affinity-chromatography

Specificity:

Histone H2B Antibody detects endogenous levels of Histone H2B

Immunogen:

A synthesized peptide derived from human Histone H2B

Description:

H2BFS a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.