Alternative Names:

H1 histone family, member O, oocyte-specific; H1FOO; H1OO; Histone H1oo; MGC50807; Oocyte-specific histone H1; Oocyte-specific linker histone H1; OSH1

Application:

WB IF/ICC

Reactivity:

Human,

Dilution:

WB 1:500-1:2000 IF/ICC 1:100-1:500

	Western blot analysis on COS7 cell lysate using Histone H1 Antibody

Purification:

Affinity-chromatography

Specificity:

Histone H1 Antibody detects endogenous levels of Histone H1

Immunogen:

A synthesized peptide derived from human Histone H1

Description:

H1FOO May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.