Alternative Names:

ACTA2,Actsa, Actvs,Actin, aortic smooth muscle,Alpha-actin-2 Cell growth-inhibiting gene 46 protein

Application:

WB IHC IF

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500~1:1000 IHC 1:200 IF 1:200

	Western blot analysis on JK using alpha-SMA antibody ,The lane on the left is blocked with the antigen-specific peptide.

Purification:

Affinity-chromatography

Specificity:

alpha-SMA antibody detects endogenous levels of alpha-SMA.

Immunogen:

Synthetic peptide corresponding to N terminal residues of Human alpha smooth muscle Actin.

Description:

Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.