Alternative Names:

DERMO1 ; MGC117334; bHLHa39

Application:

WB IHC

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500-1:1000

	Western blot analysis of extracts from A549, Hela and 3T3 cells using Twist2 Antibody

Purification:

Affinity-chromatography

Specificity:

The antibody detects endogenous level of total Twist2 protein.

Immunogen:

Peptide sequence around aa.26~30(P-K-R-F-G) derived from Human Twist2.

Description:

Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.