Alternative Names:

Interleukin-12 subunit beta; IL-12B; IL-12 subunit p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; NK cell stimulatory factor chain 2; NKSF2; IL12B; NKSF2

Application:

WB

Reactivity:

Human

Dilution:

WB 1:500-1:2000

	Western blot analysis of Interleukin 12B expression in K562 cells

Purification:

Affinity-chromatography

Specificity:

Interleukin 12B Antibody detects endogenous levels of total Interleukin 12B

Immunogen:

A synthesized peptide derived from human Interleukin 12B

Description:

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.