Alternative Names:

CD63 antigen; Melanoma-associated antigen ME491; Ocular melanoma-associated antigen; OMA81H; Granulophysin; Tetraspanin-30; Tspan-30; Lysosomal-associated membrane protein 3; Lamp-3; CD63; MLA1; TSPAN30

Application:

IHC

Reactivity:

Human

Dilution:

IHC 1:50-1:200

	Immunohistochemistry analysis of CD63 antibody in paraffin-embedded human lung carcinoma tissue.

Purification:

Affinity-chromatography

Specificity:

CD63 Antibody detects endogenous levels of total CD63

Immunogen:

A synthesized peptide derived from human CD63

Description:

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGF

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.