Alternative Names:

Twist-related protein 1; Class A basic helix-loop-helix protein 38; bHLHa38; H-twist; TWIST1; BHLHA38; TWIST

Application:

WB

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500-1:2000

	Western blot analysis of twist expression in Jurkat cells

Purification:

Affinity-chromatography

Specificity:

twist Antibody detects endogenous levels of total twist

Immunogen:

A synthesized peptide derived from human twist

Description:

Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.