Alternative Names:

CASP-8, ICE-like apoptotic protease 5, MORT1-associated CED-3 homolog, MACH, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, Caspase-8 subunit p18, Caspase-8 subunit p10, CASP8, M

Application:

WB

Reactivity:

Human

Dilution:

WB 1:500-1:2000

	Western blot analysis of Caspase 8 (Cleaved-Asp384) expression in 293 cells, treated with etoposide

Purification:

Affinity-chromatography

Specificity:

Caspase 8 (Cleaved-Asp384) Antibody detects endogenous levels of total Caspase 8 (Cleaved-Asp384)

Immunogen:

A synthesized peptide derived from human Caspase 8 (Cleaved-Asp384)

Description:

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.