Alternative Names:

AD10; ADA10; ADAM 10; ADAM metallopeptidase domain 10; ADAM10; CD156c; CDw156; Disintegrin and metalloproteinase domain-containing protein 10; HsT18717; KUZ; Kuzbanian protein homolog; MADM; Mammalian disintegrin-metalloprotease

Application:

WB

Reactivity:

Human

Dilution:

WB 1:500-1:2000

	Western blot analysis of ADAM10 expression in K562 cells

Purification:

Affinity-chromatography

Specificity:

ADAM10 Antibody detects endogenous levels of total ADAM10

Immunogen:

A synthesized peptide derived from human ADAM10

Description:

Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP).

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.