Alternative Names:

TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, I-TRAF, TANK, ITRAF, TRAF2

Application:

WB

Reactivity:

Human,Mouse,Rat

Dilution:

WB 1:500-1:2000

	Western blot analysis of I-TRAF expression in HT-29 cells

Purification:

Affinity-chromatography

Specificity:

I-TRAF Antibody detects endogenous levels of total I-TRAF

Immunogen:

A synthesized peptide derived from human I-TRAF

Description:

Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.