Alternative Names:

NOTC1, NOTCH1, TAN1, hN1, neurogenic locus notch homolog protein 1, neurogenic locus notch homolog protein 1 precursor, notch (Drosophila) homolog 1 (translocation-associated), notch homolog 1, translocation-associated (Drosophila), translocation-associat

Application:

WB,IHC

Reactivity:

Human,Mouse,Rat

Dilution:

WB 1:500-1:2000 IHC 1:50-1:200

	Western blot analysis of Notch 1 (Cleaved-Val1744) expression in NIH 3T3 cell extract treated with etoposide

Purification:

Affinity-chromatography

Specificity:

Notch 1 (Cleaved-Val1744) Antibody detects endogenous levels of total Notch 1 (Cleaved-Val1744)

Immunogen:

A synthesized peptide derived from human Notch 1 (Cleaved-Val1744)

Description:

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.