Alternative Names:

PIAS-gamma, PIASG, PIASy, protein inhibitor of activated STAT protein 4, protein inhibitor of activated STAT protein PIASy, protein inhibitor of activated STAT protein gamma, protein inhibitor of activated STAT, 4

Application:

WB,IHC

Reactivity:

Human,Mouse

Dilution:

WB 1:500-1:2000 IHC 1:50-1:200

	Western blot analysis of PIAS4 expression in Jurkat cell extract

Purification:

Affinity-chromatography

Specificity:

PIAS4 Antibody detects endogenous levels of total PIAS4

Immunogen:

A synthesized peptide derived from human PIAS4

Description:

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.