Alternative Names:

HNF 2 antibody HNF-1-beta antibody HNF-1B antibody HNF1 beta antibody HNF1 homeobox B antibody HNF1B antibody HNF1B_HUMAN antibody HNF1beta antibody HNF2 antibody Homeoprotein LF B3 antibody Homeoprotein LFB3 antibody HPC11 antibody LF B3 antibody LFB3 an

Application:

WB,IF

Reactivity:

Human

Dilution:

WB 1:500-1:2000 IF 1:100-1:500

	Western blot analysis of HNF1 beta expression in Human liver lysate

Purification:

Affinity-chromatography

Specificity:

HNF1 beta antibody detects endogenous levels of total HNF1 beta

Immunogen:

A synthesized peptide derived from human HNF1 beta

Description:

Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD) [MIM:137920]; also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5).

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.