Alternative Names:

bHLHe73;ECYT4;EPAS 1;EPAS1;HIF2A;HLF;MOP 2;PASD2

Application:

WB ICC/IF FC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:50

	Western blot analysis of HIF-2 alpha in (1)MCF-7 cell lysate;(2)HeLa cell lysate.

Purification:

Affinity-chromatography

Specificity:

HIF-2-alpha Antibody detects endogenous levels of total HIF-2-alpha

Immunogen:

A synthesized peptide derived from human HIF-2 alpha

Description:

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.