Alternative Names:

GLSS; SATB family member 2; SATB homeobox 2; SATB2;Special AT rich sequence binding protein 2;

Application:

WB IHC ICC/IF

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

	Western blot analysis of SATB2 expression in Saos-2 cell lysate.
	Immunohistochemical analysis of paraffin-embedded human stomach cancer, using SATB2 Antibody.
	Immunofluorescent analysis of SH-SY5Y cells, using SATB2 Antibody .

Purification:

Affinity-chromatography

Specificity:

SATB2 Antibody detects endogenous levels of total SATB2

Immunogen:

A synthesized peptide derived from human SATB2

Description:

Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.