Alternative Names:

kinase ATM; Serine-protein kinase ATM

Application:

WB IHC ICC/IF IP

Reactivity:

Human

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

	Western blot analysis of Phospho-ATM (Ser1981) in (1) HEK293 cell lysate; (2) HEK293 cell lysate treated with Doxorubicin.
	Immunohistochemical analysis of paraffin-embedded human liver, using Phospho-ATM (S1981) Antibody.

Purification:

Affinity-chromatography

Specificity:

Phospho-ATM (S1981) Antibody detects endogenous levels of total Phospho-ATM (S1981)

Immunogen:

A synthesized peptide derived from human Phospho-ATM (S1981)

Description:

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.