Alternative Names:

PMEL; ME20-M; Premelanosome protein; Silver locus protein homolog; PMEL17; SILV;

Application:

WB IHC

Reactivity:

Human

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200

	Western blot analysis of PMEL17 / GP100 expression in human melanoma lysate.
	Immunohistochemical analysis of paraffin-embedded human melanoma, using PMEL17 / GP100 Antibody.

Purification:

Affinity-chromatography

Specificity:

PMEL17 / GP100 Antibody detects endogenous levels of total PMEL17 / GP100

Immunogen:

A synthesized peptide derived from human PMEL17 / GP100

Description:

Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.