Alternative Names:

TOR1A;DQ2; DYT1; TorsinA;

Application:

WB FC

Reactivity:

Human

Dilution:

WB 1:500~1:2000 FC 1:50

	Western blot analysis of Torsin A expression in 293T cell lysate.

Purification:

Affinity-chromatography

Specificity:

Torsin A Antibody detects endogenous levels of total Torsin A

Immunogen:

A synthesized peptide derived from human Torsin A

Description:

The neurological condition Dystonia is associated with sustained muscle contractions and abnormal posturing. TorsinA, torsinB, torp2A and torp3A belong to the family of ATPases associated with cellular activites (AAA+) and mutations in torsinA cause early onset dystonia. TorsinA has been shown to suppress intracellular protein aggregation in C. elegans and possesses chaperon activity. Interestingly, torsinA is highly expressed in dopaminergic neurons and associates with alpha-synuclein in Lewy bodies, which pathologically characterize Parkinson's Disease.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.