Alternative Names:

A2MR; alpha 2MR; Alpha 2 macroglobulin receptor; CD91; APR; LRP1; LRP85; TGFBR5;

Application:

WB IHC ICC/IF IP FC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:10000~1:20000 IHC 1:50~1:100 ICC/IF 1:50~1:100 IP 1:30 FC 1:50

	Western blot analysis of LRP1 expression in A549 cell lysate.
	Immunohistochemical analysis of paraffin-embedded human liver carcinoma, using LRP1 Antibody.

Purification:

Affinity-chromatography

Specificity:

LRP1 Antibody detects endogenous levels of total LRP1

Immunogen:

A synthesized peptide derived from human LRP1

Description:

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.