Alternative Names:

EC 2.7.11.1 Interferon-inducible RNA-dependent protein kinase Eukaryotic translation initiation factor 2-alpha kinase 2 eIF-2A protein kinase 2 Protein kinase RNA-activated PKR p68 kinase P1/eIF-2A protein kinase

Application:

WB IHC

Reactivity:

Human

Dilution:

WB 1:500-1:2000 IHC 1:50-1:200

	Western blot analysis of PKR expression in Starvation treated K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

Purification:

Affinity-chromatography

Specificity:

PKR Antibody detects endogenous levels of total PKR

Immunogen:

A synthesized peptide derived from human PKR

Description:

PKR a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.