Alternative Names:

IRS-1, IRS1, Insulin receptor substrate-1

Application:

IHC

Reactivity:

Human, Mouse, Rat

Dilution:

IHC 1:50-1:200

	Western blot analysis of IRS-1 expression in whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

Purification:

Affinity-chromatography

Specificity:

IRS-1 Antibody detects endogenous levels of total IRS-1

Immunogen:

A synthesized peptide derived from human IRS-1

Description:

IRS-1 is an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.