Alternative Names:

CAP20; CDK-interacting protein 1; CDKN1; CDKN1A; CDN1A; CIP1; Cyclin-dependent kinase inhibitor 1; MDA-6; MDA6; Melanoma differentiation associated protein; Melanoma differentiation

Application:

WB

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500-1:2000

	Western blot analysis of p21 Cip1 expression in EGF treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

Purification:

Affinity-chromatography

Specificity:

p21 Cip1 Antibody detects endogenous levels of total p21 Cip1

Immunogen:

A synthesized peptide derived from human p21 Cip1

Description:

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.